2024

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Total Synthesis

  1. Evolution of the Short Enantioselective Total Synthesis of the Unique Marine Myxobacteria Polyketide Salimabromide

    Kang-Ji Gan, Yao Zhu, Gaosheng Shi, Changhui Wu, Fu-Qiang Ni, Li-Han Zhao, Xiaowei Dou, Zhihan Zhang,* Hai-Hua Lu *

    Chin. J. Chem. 2025, 43, 79－89

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Palladium-catalysis, Orbital Interactions, axial chirality

  1. Synthesis of Chiral Endocyclic Allenes and Alkynes via Pd-Catalyzed Asymmetric Higher-Order Dipolar Cycloaddition

    Bin Shi,$^\dagger$ Meng Xiao,$^\dagger$ Jin-Pu Zhao, Zhihan Zhang,* Wen-Jing Xiao, and Liang-Qiu Lu* ($^\dagger$co-first authors)

    J. Am. Chem. Soc. 2024, 146, 26622–26629.

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Cobalt-catalysis, Orbital Interactions, Spin Effects, Radical Transformations

  1. Cobalt-Catalyzed Regio-, Diastereo- and Enantioselective Reductive Coupling of 1,3-Dienes and Aldehydes

    Yu Wang, Danrui Wang, Shilin Wang, Qinglei Chong,* ZhihanZhang,* and Fanke Meng*

    Angew. Chem. Int. Ed. 2024, e202413313

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Metal-free, Orbital Interactions

  1. Hyperconjugation-Driven Isodesmic Reaction of Indoles and Anilines: Reaction Discovery, Mechanism Study, and Antitumor Application

    Yu-Qing Xiao,$^\dagger$ Kai-Xin Fang,$^\dagger$ Zhihan Zhang,$^\dagger$ Chen Zhang, Yu-Jie Li, Bao-Cheng Wang, Bin-Jun Zhang, Yu-Qing Jiang, Miao Zhang, Ying Tan,* *Wen-Jing Xiao, and Liang-Qiu Lu ($^\dagger$co-first authors)

    Angew. Chem. Int. Ed. 2024, e202408426

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Cobalt-catalysis, Spin Effects, MHAT

  1. Cobalt-Catalyzed Chemo- and Stereoselective Transfer Semihydrogenation of 1,3-Dienes with Water as a Hydrogen Source

    Heng Wang,$^\dagger$ Xiaofeng Jie,$^\dagger$ Ting Su, Qianghui Wu, Jian Kuang, Zhao Sun, Yingying Zhao, Qinglei Chong,* Yinlong Guo,* Zhihan Zhang,* and Fanke Meng* ($^\dagger$co-first authors)

    J. Am. Chem. Soc. 2024, 146, 23476-23486.

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Cobalt-catalysis

  1. Cobalt-Catalyzed Enantioselective Alkenylation of Aldehydes

    Chuiyi Lin, Jiwu Zhang, Zhao Sun, Yinlong Guo,* Qinglei Chong,* Zhihan Zhang,* and Fanke Meng*

    Angew. Chem. Int. Ed. 2024, 63, ****e202405290

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Copper-catalysis, Radical Transformations

  1. Photoinduced Copper-Catalyzed Asymmetric Three-Component Radical 1,2-Azidooxygenation of 1,3-Dienes

    Guo-Qing Li, Zi-Qing Li, Prof. Min Jiang, Zhihan Zhang, Yu Qian, Wen-Jing Xiao, Jia-Rong Chen*

    Angew. Chem. Int. Ed. 2024, 63, e202405560

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Cobalt-catalysis, Spin-effects, MHAT, Orbital Interactions

  1. Enantioselective synthesis of chiral α,α-dialkyl indoles and related azoles by cobalt-catalyzed hydroalkylation and regioselectivity switch

    Jiangtao Ren, Zheng Sun, Shuang Zhao, Jinyuan Huang, Yukun Wang, Cheng Zhang, Jinhai Huang, Chenhao Zhang, Ruipu Zhang, Zhihan Zhang,* Xu Ji* & Zhihui Shao*

    Nat. Commun. 2024, 15, 3783

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Metal-free, Orbital Interactions

  1. Asymmetric Cascade Cyclization of Enynamides with Photogenerated Ketenes via Relay Gold and N -Oxide Catalysis

    Dan Liu,$^\dagger$ Zhen-Cao Shu,$^\dagger$ Zhihan Zhang,$^\dagger$ Ze-Tian Wang, Liang Wang, Ming-Sheng Xie,* Hai-Ming Guo, Liang-Qiu Lu,* and Wen-Jing Xiao* ($^\dagger$co-first authors)

    ACS Catal. 2024, 14, 1741−1749